High affinity copper uptake protein 1-like
Web24 de jun. de 2003 · The hCtr1 protein functions in high affinity copper uptake. Copper is delivered by an unknown mechanism to three different metallochaperones, hCCS, ATOX1 and hCOX17. The delivery of copper to SOD1 is mediated by hCCS. The pathway involving copper delivery to cytochrome oxidase in the mitochondria requires the hCOX17 copper … WebHigh affinity copper uptake protein 1 Gene SLC31A1 Status UniProtKB reviewed (Swiss-Prot) Organism Homo sapiens (Human) Amino acids 190 Protein existence Evidence at …
High affinity copper uptake protein 1-like
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Web28 de nov. de 2024 · DOI: 10.3389/fmolb.2024.1055356 Abstract More than a decade ago, studies on cellular cisplatin accumulation via active membrane transport established the role of the high affinity copper uptake protein 1 (CTR1) as a main uptake route besides passive diffusion. Web13 de abr. de 2024 · Expression and affinity purification of recombinant proteins. Recombinant proteins were purified by Ni-NTA affinity column (detected by western blot). The gel was stained with Coomassie brilliant blue G250 (CBB G250). (A) Western blot analyses of the recombinant Rh14-3-3ζ and Rh14-3-3ε protein.
WebIt has been claimed that human copper transporter 1 (hCTR1), the human high-affinity copper transporter, is the major entry pathway for cDDP and related drugs via a mechanism that mimics copper. This is an unexpected property of … Web1 de jan. de 2024 · This high-affinity copper transporter takes up Cu + from the intestinal lumen to the epithelial cell, in an energy-independent manner [2], [3]. CTR1 is the major copper importer present on the apical site of enterocytes, but conflicting reports have also shown a possible role of DMT1 in copper transfer into intestinal cells.
WebCopper is imported into eukaryotic cells through high-affinity copper transporters of the family of Ctr permeases. 9 To date, Ctr transporters are the best-characterized system … WebGene ID: 102804936, updated on 5-Feb-2024. Summary Other designations. high affinity copper uptake protein 1-like
WebCopper (Cu) is an essential trace element for growth and development and abnormal Cu levels are associated with anemia, metabolic disease and cancer. Evolutionarily …
WebHigh affinity copper uptake protein 1: Synonyms: Copper transporter 1; Solute carrier family 31 member 1; hCTR1; Gene Name: SLC31A1: Protein Type: Transporter: Biological Properties; ... structure of the human copper transporter CTR1 at 6-A resolution reveals a compact trimer with a novel channel-like architecture. church in new mexicoWebChemokines and chemokine receptors have been recognized as critical signal components that maintain the physiological functions of various cells, particularly the immune cells. The signals of chemokines/chemokine receptors guide various leukocytes to respond to inflammatory reactions and infectious agents. Many chemokine receptors play supportive … dev shell launcherWeb15 de abr. de 2024 · High affinity copper uptake protein 1 (pig) Protein Target - PubChem Apologies, we are having some trouble retrieving data from our servers... devshell_project_idWebsible that the fusion of S. cerevisiae Ctr1 and Ctr3-like proteins may be an early event that led to the evolution of high affinity copper transport proteins of other eukaryotes (15, 17). Since most eukaryotic high affinity copper transporters iden-tified to date have strong homology to Ctr3, it is important to church in new mexico with staircaseWeb30 de mar. de 2024 · Functional assays revealed that it stimulates the initial rate of radiolabeled copper uptake. CTR1 transports copper with high affinity in a time-dependent and saturable manner and is copper-specific. Transport is an energy-independent process and is stimulated by extracellular acidic pH and high K+ … church inn festive menuHigh affinity copper uptake protein 1 (CTR1) is a protein that in humans is encoded by the SLC31A1 gene. Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and … Ver mais In 2024, a new autosomal-recessive disease was discovered that is caused by mutations of the CTR1 gene. The disease is characterized by profound deficiency of copper in the central nervous system and presents with … Ver mais • Solute carrier family Ver mais • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". … Ver mais church inn ford laneWeb17 de nov. de 2024 · The expression of the high affinity Cu uptake system is transcriptionally regulated by a copper metalloregulatory transcription factor (CuMRTF) named ScMac1 ( Labbe et al., 1997; Keller et al., 2005 ). In the absence of copper, ScMac1 is able to bind DNA, thereby activating the expression of the high affinity Cu uptake … church in new york ca