Cytoplasmic retention site
WebNational Center for Biotechnology Information WebMar 1, 2013 · Huntington disease is a dominantly inherited neurodegenerative condition caused by polyglutamine expansion in the N terminus of the huntingtin protein (Htt). The first 17 amino acids (N17) of Htt play a key role in regulating its toxicity and aggregation. Both nuclear export and cytoplasm retention functions have been ascribed to N17.
Cytoplasmic retention site
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WebThe cytoplasmic retention of the precursor molecule is controlled by a small region in its C-terminal part. We show that this region is responsible for the observed lack of DNA … Mitotic entry is determined by a threshold level of active cyclin-B1/CDK1 complex, also known as cyclin-B1/Cdc2 or the maturation promoting factor (MPF). Active cyclin-B1/CDK1 triggers irreversible actions in early mitosis, including centrosome separation, nuclear envelope breakdown, and spindle assembly. In vertebrates, there are five cyclin B isoforms (B1, B2, B3, B4, and …
WebWith regard to the mechanism behind nuclear DDX3 retention, we observed a correlation between cytoplasmic expression of CRM1 and nuclear DDX3 expression in colorectal cancer. This suggests that dysregulation of CRM1 is one of the mechanisms of nuclear DDX3 expression. The binding site of DDX3 to CRM1 is a matter of debate. WebNov 6, 2009 · Consistently, we show that hnRNP A1 acts as an internal ribosomal entry site trans-acting factor up-regulating internal ribosome entry site-mediated translation initiation of the HIV-1 vRNA. The up-regulation and cytoplasmic retention of hnRNP A1 by HIV-1 would ensure abundant expression of viral structural proteins in cells infected with HIV-1.
WebJun 20, 2000 · Retention by STAT2 may serve to regulate the activity of free p48 and/or guarantee that cytoplasmic pools of preassociated STAT2:p48 are available for rapid … WebMay 15, 2024 · Nucleo-cytoplasmic shuttling of transcription factors is used by the cell to control gene expression programs in response to the environment. Transcription factors exert their function primarily in the nucleus; however, under some conditions, they may be localized in the cytoplasm.
WebMar 21, 2024 · Intriguingly, our results showed that USP11 could be phosphorylated by ERK1/2 at the Ser905 site and led to its cytoplasmic retention. This is critical for stabilizing cytoplasmic p21 levels because inhibition of USP11 phosphorylation mediated by ERK1/2 not only caused a decrease of USP11 in the cytoplasm but also resulted in a …
WebJun 20, 2000 · Retention by STAT2 may serve to regulate the activity of free p48 and/or guarantee that cytoplasmic pools of preassociated STAT2:p48 are available for rapid activation of the IFN response. These findings suggest that analogous mechanisms may exist for regulating the distribution of other IRF proteins. software repair world ukWebAug 1, 1999 · The MA domain of these viruses contains a "cytoplasmic targeting and retention signal (CTRS)" which is necessary for the intracytoplasmic assembly of virus … slowly to a maestro crosswordWebJun 1, 2024 · Nucleo‐cytoplasmic shuttling of transcription factors is used by the cell to control gene expression programs in response to the environment. Transcription … slowly to a maestroWebThis new understanding of the determinants of nuclear retention and cytoplasmic export provides a deeper understanding of how information flow is regulated in eukaryotic cells. … slowly thinkingWebMicrotubules Emanate from the Centrosome in Animal Cells. In most animal cells, there is a single, well-defined MTOC called the centrosome, located near the nucleus.From this … software repair world reviewsWeb... data above demonstrated that the loss of Hippo signaling in the liver resulted in the cytoplasmic retention of both Skp2 and FoxO through the activation of Akt, which promotes Skp2-mediated... software_reporter_tool.exe 停止WebJan 1, 2005 · If the droplet is normally shed then its retention on sperm in the ejaculate may be associated with infertility, and there is considerable evidence that this is the … slowly to a maestro crossword clue