http://web.mit.edu/chemistry/alberty/ WebThe formulation scientist’s key goal is to achieve long-term stability of a drug compound. In the case of protein drugs, stabilization means not only maintaining the native chemical structure, but the native secondary and higher order structures necessary for biological activity ( Cleland et al., 1993; Manning et al., 1989 ).

Physical Stabilization of Proteins in Aqueous Solution

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WebThe researchers in the Department of Biophysics & Biophysical Chemistry address fundamental biological problems at a mechanistic level, using cutting-edge tools … WebIn this study we introduce a mesoscopic lipid-water-alcohol model. Dissipative particle dynamics (DPD) simulations have been used to investigate the induced interdigitation of bilayers consisting of double-tail … WebJun 19, 2007 · Crystal Structure of Acot7 N Domain. We separately crystallized and determined the structures of N- and C-domains of Acot7 at 1.8 and 2.5 Å resolution, respectively [supporting information (SI) Table 1].The N-domain monomer features a five-stranded antiparallel β-sheet surrounding an α-helix (Fig. 1 a).There is an additional C … high density upholstery foam for couch