Bioisosterism翻译
WebSuch substitution of =N for CH= is an example of the common medicinal chemical strategy known as bioisosterism. [Pg.278] Further development in the chemistry of oxazolidinone antibacterials was based mainly on the assumption that the 4-pyridyl moiety of one of Dupont s lead compounds , E-3709, might be amenable to replacement by suitably … WebBioisosterism is a unique approach used by medicinal chemists for the reasonable modification of lead compounds into safer, more clinically effective, economical, and therapeutically attractive drugs. It is one of the most crucial lead modification tools, widely applied in the field of rational drug design to amplify the desired activity and eliminate …
Bioisosterism翻译
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Web1 Jul 2001 · It is now half a century since Friedman introduced the term bioisosterism for the similar biological activity of structurally related compounds. Since then, the concept has been used extensively and successfully in the optimization of lead compounds in drug discovery. The number of chemical lead compounds has expanded enormously in recent … WebSpringer
http://www.dictall.com/indu/077/076640249C2.htm Web14 Mar 2024 · bioisosterism. ( pharmacology) The relationship between bioisosteres, substituents or groups with similar physical or chemical properties that impart similar …
Web31 Mar 2024 · The relationship between bioisosteres is known as bioisosterism. In drug design Bioisosterism plays very importance role. Its help in increases the required biological or physical property of a drug without changing the chemical structure. Bioisosterism also help to reduced the toxicity which changes or alter the bioavailability … WebA bioisostere is a compound resulting from the exchange of an atom or of a group of atoms with another, broadly similar, atom or group of atoms.. Alfred Burger, in Progress in Drug Research, offered a definition of bioisosterism in 1991 as follows: "Compounds or groups that possess near-equal molecular shapes and volumes, approximately the same …
WebDefinition of Bioisosterism Friedman (1951): Bioisosteresare atoms or molecules that fit the broadest definition for isosteresand have the same type of biological activity. Thornber(1979): Groups or molecules which have chemical and physical similarities producing broadly similar biological effects. Parameters affected with …
Web17 Nov 2012 · Friedmann and Thornber described bioisosterism as a form of non-classical isosterism with relation to the modulation of a biological endpoint. Since then, interest and research on this concept have been gradually increasing, and efforts have been put into collecting anecdotes of historically successful applications. Several ... reserve at peachtree cornersWeb"同名" 英文翻译: of the same name; synonym; homonym 根据同名小说摄制的电影 a film based on a novel of the same name; 他和我同名。 he is my namesake he is my namesake "异物" 英文翻译 : 1.[医学] foreign matter; foreign body 他眼睛里有异物。 prosthetic joint infection icdWebA.G. Leach, ... E.J. Griffen, in Comprehensive Medicinal Chemistry III, 2024 3.10.4.2 Bioisosteres. Bioisosteres have a long history in medicinal chemistry and have been … reserve at park westWebbioisosterism 所属学科 化学、生物学、药学 应用领域 农药、医药等 开始发展 20世纪20年代 作 用 通过替换基团改变化合物结构 reserve at perona farmsWeb生物电子等排体名词解释药物化学. 生物电子等排体是指外层电子数目相等的原子、离子、分子，以及具有相似立体和电子构型的基团，例如，—coo—、—co—、—nh—、—ch2—等基团是生物电子等排体，—cl、—br、—ch3等也是生物电子等排体。 prosthetic joint infection icd 10Web10 Nov 2016 · 1. BIOISOTERISM:A useful strategy for drug design 1. 2. In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or … prosthetic joint infection icd codeWebIsosterism and bioisosterism in drug design. 303. The proposal that there is a skeletal center of a molecule (a pharmacophore) equipped with substituents and that these substituents make additive quantitative contributions to the biological activity has been in the minds of medicinal chemists for a long time. reserve at rancho belago